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NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor
doi:10.1038/s41598-024-65310-y Neelakantan H, Hommel JD, Watowich SJ, et al
It removes the dependency on conversion and reduces the likelihood of metabolic bottlenecks
By inhibiting NNMT activity, 5-Amino-1MQ has been investigated for its potential to alter intracellular nicotinamide metabolism, increase nicotinamide adenine dinucleotide (NAD) availability, and improve mitochondrial energy utilization
S2), this trend did not rise to the level of statistical significance
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