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It signals your brain to reduce hunger, slows stomach emptying so you feel full longer, and helps regulate blood sugar levels
BIDANI, A.K., PICKEN, M., HACIOGLU, R., WILLIAMSON, G
Dynamics and ecological reassembly of the human gut microbiome and the host metabolome in response to prolonged fasting
Upregulated: collagen synthesis genes (COL1A1, COL3A1), antioxidant genes (SOD1, SOD3), DNA repair genes (GADD45A) Downregulated: inflammatory cytokines (IL-6, TNF-), metalloproteinases (MMP-2, MMP-9), pro-fibrotic mediators Net effect: shift from tissue destruction and inflammation toward repair and remodeling This breadth of gene modulation is unusual for a single tripeptide and has generated significant research interest in fields ranging from dermatology to neuroscience
Many people see appetite changes within a week or two
What the Science Shows If SCFAs drive GLP-1, and gut bacteria make SCFAs, then a reasonable question follows: can adding beneficial bacteria increase GLP-1
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