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Without sufficient methylfolate and vitamin B12, MTR wont convert as much homocysteine to methionine, leading to a buildup of homocysteine and limiting methionine

57 SilvaT.Cavalcanti FilhoJ.Barreto FonscaM.SantosN.Barbosa da SilvaA.ZagmignanA.et al (2020)

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Functional assessments reveal cartilage generated by FOXO4-DRI-pretreated chondrocytes displays significantly lower senescence levels compared to cartilage from untreated cells