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However, previous studies have not investigated GLP-1 analogs and exendin 939 for pain transmission at peripheral sites, especially in small-sized nociceptive DRG neurons, where the TRPV1 channel is crucial in chronic pain-induced mechanical allodynia and thermal hyperalgesia 58,59,60,61

Tirzepatide, a dual GIP and GLP-1 receptor agonist licensed for type 2 diabetes, and phentermine, an unlicensed sympathomimetic appetite suppressant, work through entirely different mechanisms

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