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AOD-9604 has been tested in over 900 human participants across six randomized, double-blind, placebo-controlled trials
2 Otoprotection in Zebrafish Lateral Line Hair Cells Uribe et al., Frontiers in Cellular Neuroscience (2015) This paper from the Coffin laboratory (with WSU co-authors) tested whether Dihexa could protect zebrafish lateral line hair cells (homologous to mammalian inner ear hair cells) from aminoglycoside-induced ototoxicity
[10] Enzyme-inducing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, as well as rifampicin, accelerate hepatic catabolism of vitamin D, shortening its half-life and potentially necessitating more frequent or higher intramuscular doses to sustain target 25-hydroxyvitamin D levels
Concentrations of GHK-Cu in the body decline significantly with age, from approximately 200 ng/mL in young adults to under 80 ng/mL by age 60, making topical replenishment meaningful
Lang E, Lang F