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It also reduces the production of inflammatory cytokines, chemokines, and the infiltration of immune cells in tissues, resulting in a broad range of neuroprotective and anti-inflammatory effects

As 2025 draws to a close, it is becoming clear that the US and EUs approval rates for innovative medicines will be markedly lower than they were in 2024

Newer compounds may attempt to influence several pathways at once

NICE recommended tirzepatide for patients with difficult to manage type 2 diabetes last year after taking into account additional data and modelling on cost effectiveness from manufacturers Eli Lilly

2017;32(suppl 1):703

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications that mimic the action of the naturally occurring incretin hormone GLP-1