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Published by Eli Lilly in December 2025, the results showed: Average weight loss of 28.7% at the 12mg dose over 68 weeks comparable to TRIUMPH-1 at the same dose Significant reductions in WOMAC pain scores a validated measure of knee pain and function More than 1 in 8 patients on retatrutide were completely free of knee pain by the end of the trial compared with less than 1 in 25 on placebo Significant improvements in physical function, stair climbing, and walking distance This matters clinically because knee osteoarthritis and obesity are deeply intertwined each kilogram of body weight lost reduces knee joint load by approximately 4 kilograms during walking

Plus, improved insulin sensitivity and less fat inside muscle fibers suggest the muscle quality improves, lowering the risk of weakness

Kueh MT, Chew NW, Al-Ozairi E, le Roux CW

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Clinical trial data from the STEP 1 extension study showed that after discontinuing semaglutide 2.4 mg, approximately two-thirds of weight loss was regained within one year

Barton, M