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In comparison to subcutaneous injection, oral administration of EGCG resulted in lower hepatotoxicity, with significant liver damage observed only in mice receiving 108 mg/kg EGCG orally
Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)
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M.FuY.WangT.et al (2005)
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