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In the USA, more than 40% of adults are obese, with projections indicating that one in two people will be affected by 2030 (refs

Primary discontinuation was defined as the first date a patient went 60 days or more without any GLP-1based treatment on hand, using fill dates and number of days of medication supplied to account for excess (carryover) medication from previous fills

Comparing Common Side Effects Know this first: As both drugs are GLP-1 agonists and work in almost the same way, side effects tend to be pretty similar overall

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weight loss (Phase 2/3 peak) | ~15% | ~22% | ~24% | | FDA Status | Approved (Wegovy, Ozempic) | Approved (Zepbound, Mounjaro) | Phase 3 (2026) | | Dosing frequency | Weekly | Weekly | Weekly | The additional glucagon receptor agonism is believed to be responsible for retatrutide's greater metabolic rate increase and enhanced fat oxidation compared to dual agonists

or severe abdominal pain that doesn't improve with dietary changes