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Rather than acting within a single pathway, these compounds are studied for their roles across interconnected systems, where inflammatory signaling, tissue adaptation, and immune modulation form a continuous network

Resta-Lenert S, Barrett KE: Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells

More recent DSIP publications have largely involved mechanistic, analogue-based, or animal-model research rather than modern large-scale human therapeutic trials

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