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129 In studies using 3T3-L1 cells, resveratrol treatment significantly decreased lipid accumulation, down-regulated the expression of C/EBP, LPL, FAS, and SREBP-1c through activation of AMPK, 130 decreased phosphorylation of MAPKs, and reduced Rb phosphorylation, 131 suppressed hormonal-induced AKT activation and cell proliferation, and inhibited cell entry into the S phase and the S to the G2/M phase transition

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Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors, currently unapproved by the MHRA, EMA, or FDA for routine clinical use