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Obwohl diese Medikamente seit fast zwei Jahrzehnten zur Behandlung von Typ-2-Diabetes eingesetzt werden, wurden sie erst 2021 von der US-amerikanischen FDA zur Behandlung von Adipositas zugelassen

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These approaches can make the medication easier to tolerate without reducing its effectiveness

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For example, the GST enzymes, part of phase II detoxification, are upregulated by the Nrf2 pathway.[ref][ref] Direct antioxidant effects: In addition to activating endogenous antioxidants via the Nrf2 pathway, sulforaphane also has some direct antioxidant properties, as it can scavenge free radicals and reactive oxygen species (ROS)

doi:10.21053/ceo.2021.01459