When NNMT activity is elevated as documented in obese adipose tissue, several cancer types, and aged skeletal muscle intracellular NAD+ availability decreases, SAM availability decreases, and downstream sirtuin activity (particularly SIRT1 and SIRT3) is reduced
+ - NNMT inhibitors are emerging as a promising area of research with potential therapeutic applications across a range of diseases
Whether chronic use affects normal age-related changes in metabolism, body composition, or health cannot be determined from current data
NAD+ is a coenzyme every cell uses to produce energy and run repair and metabolism
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