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These may include nausea, decreased appetite, vomiting, constipation, diarrhea, bloating, or abdominal discomfort

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Open Medicine, 18 (1), Article 20230692

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Such a strategy has been demonstrated in the case of cholangiocarcinoma, where IDH1 mutations resulted in the production of the oncometabolite 2-hydroxyglutarate, leading to epigenetic alterations and changes in the expression of key genes involved in cell differentiation and survival [202]

This safety profile makes them a preferred option for men who need to control their blood sugar levels without the constant worry of dropping too low