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In addition to their potent metabolic actions that reduce hyperglycaemia and body weight, GLP-1RAs also lower the risk of major kidney, cardiovascular and mortality outcomes across broad populations with cardiovascular disease or CKD, with and without diabetes or obesity
Additionally, individual patient factorssuch as cardiovascular health, psychiatric history, and treatment goalsplay a critical role in determining safety
Neural mechanisms underlying hyperphagia in prader-willi syndrome
Commenting on PRACs recommendations, a spokesperson for Novo Nordisk said: Based on the totality of evidence, we concluded that the data did not suggest a reasonable possibility of a causal relationship between semaglutide and NAION and that the benefit-risk profile of semaglutide remains favourable
A physiological role of glucagon-like peptide I
