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Gastroparesis and severe GI motility problems on tirzepatide In December 2025, the FDA updated both the Mounjaro and Zepbound prescribing information to add a specific warning about severe gastroparesis (Section 5.6): tirzepatide is not recommended for people with pre-existing severe gastroparesis
and Napolioni, V
However, they both show increased risk of micro- & macrovascular complications that can be alleviated by optimized BP control
Many patients are frustrated when they must explicitly request medications by name rather than having their doctor proactively offer appropriate options based on their medical history
The more refined this audience is, the more likely you will make a conversion
Lillys pursuit of small-molecule GLP-1s like orforglipron indicates a strategic move to fully chemical manufacturing, which if successful could shift manufacturing out of peptide processes entirely
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