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If 1 million people in the UK are on GLP-1 therapy, wed expect around 560 cases yearly or about 50 a month regardless of medication

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Its a tripeptide

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PMID 7540205

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Alteration of the Remethylation Pathway Rare forms of homocystinuria resulting from alterations of the remethylation pathway have been described

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Ozempic is the only FDA-approved oral peptide GLP-1 medication for adults with type 2 diabetes indicated not only to improve blood sugar, along with diet and exercise, but also to reduce the risk of major cardiovascular events (MACE) such as heart attack, stroke, or death in those who are also at high risk for these events.1 Oral semaglutide for type 2 diabetes has been available as Rybelsus in a different formulation and set of doses

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