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The study reveals that the SLC25A39 transporter, which imports glutathione into mitochondria, is essential for cancer spread, and elevated SLC25A39 expression correlates with poorer survival outcomes in breast cancer patients, suggesting potential therapeutic targeting opportunities
doi: 10.3389/fmolb.2025.1639327 Received 07 June 2025 Accepted 04 July 2025 Published 22 July 2025 Volume 12 - 2025 Edited by Venkaiah Betapudi, United States Department of Health and Human Services, United States Reviewed by Anderson Oliveira Souza, Federal University of Mato Grosso, Brazil Raffaella Scanga, University of Calabria, Italy Danish Idrees, University of Iowa Healthcare, United States Rahul Patil, Augusta State University, United States Updates Copyright 2025 Seneff and Kyriakopoulos
Glutathione therapy delivers antioxidant and regeneration support
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This was evidenced by reduced levels of ferroptosis markers such as MDA and iron, along with repressed CHAC1 expression (Zhou, Y
The qRT-PCR primer sets for cDNA amplification were as follows: TNF- (forward: 5-TCCAGGCGGTGCCTATGT-3/reverse: 5-CACCCCGAAGTTCAGTAGACAGA-3), IL-6 (forward: 5-CTGCAAGAGACTTCCATCCAGTT-3/reverse: 5-AAGTAGGG AAGGCCGTGGTT-3), IFN- (forward: 5-TCAAGTGGCATAGATGTGGAAGAA-3/reverse: 5-TGGCTCTGCAGGATTTTCATG-3), CXCL2 (forward: 5-CTCAGTGC TGCACTGGTCCTG-3/reverse: 5-CTGGGGGCGTCACACTCAAG C-3), and GAPDH (forward: 5-CCTCGTCCCGTAGACAAAATG-3/reverse: 5-TCTCCACTTT GCCACTGCAA-3)
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