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PubMed.gov .

Nausea is the most frequent side effect, affecting around 44% of people at the full dose, but it usually improves within 4 to 8 weeks

For compounded semaglutide specifically, the practical guidance breaks down like this: Under 30 minutes at room temperature (below 77F/25C): Almost certainly fine

In one balanced Cleveland Clinic chart-review sample of 288 discontinuers, cost or insurance was documented for 47.6%, side effects for 14.6%, and shortages for 11.8%