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identified a previously unculturable gram positive bacterium (KLE1738) that required a common GABA-producing gut microbe -Bacteroides fragilis- to grow in vitro (95) versus its role in neuroendocrine signaling and immune regulation (96)
When that happens, she explains, the goal isnt to stop treatment but to adjust it
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The most serious risk, lactic acidosis, is extremely rare (estimated at 1-5 cases per 100,000 patient-years) and occurs almost exclusively in patients with severe kidney impairment or acute illness
Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
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