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PMID: 25370536, PMCID: PMC4239317, DOI: 10.1186/s12913-014-0506-4

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In most tumors, the activity and expression of HMGCR are enhanced, thereby increasing the supply of key downstream metabolites that modulate lipid metabolism to promote cell proliferation and transformation, ultimately accelerating cancer progression (68)

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This was administered at approximately one hour before the 1% carrageenan induction, which was injected through the intraplantar route into the right hind leg of the rat at 0.1 ml