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hiPSCs carrying loss-of-function mutations in DEPDC5 , encoding a GATOR1 complex member, show overactivation of the mammalian target of rapamycin complex 1 (mTORC1) signaling node, resulting in epileptic episodes which can be alleviated by administering the mTORC1 inhibitor rapamycin (Klofas et al., 2020)

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Estrogen receptor mutations in tamoxifen-resistant breast cancer

Ferroptosis could be induced by directly supplementing the cell's active iron pool to establish an iron overload state