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Research indicates that the absorption and bioavailability of LC are maximized at "small dose" supplementation, where carrier-mediated transport dominates at low concentrations, maintaining a substantial degree of linearity (Parkhouse and McKenzie 1984)

"It would actually surprise me if this followed the traditional pathway of formal rulemaking," Dresser told NPR

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In the CNS, endocannabinoids mediate retrograde signaling that begins with the synthesis of 2-AG or AEA in the postsynaptic membrane