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REDEFINE 1, in adults with overweight or obesity without diabetes, reported 22.7% mean weight loss for the combination at 68 weeks on the on-treatment analysis, with 60% of combination participants reaching at least 20% loss and 23% reaching at least 30% (Aronne et al., 2025)
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Most people in the general population can get enough vitamin B12 from a balanced diet
Together, these findings indicate that HGF and possibly other growth factors hold promise for treating the neurocognitive sequela following TBI as small molecule HGF/MET activators currently in clinical trials may provide an accelerated path for testing its clinical efficacy in TBI patient populations 40
doi:10.1007/s12015-025-10911-x
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