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A genome-wide pharmacogenomic study published in The Lancet Diabetes & Endocrinology identified two loci with significant effects on HbA1c response to GLP-1 RA treatment across 4,571 patients: the Gly168Ser variant in GLP1R (rs6923761), which reduces receptor signaling efficacy, and a low-frequency variant in ARRB1 (Thr370Met
Often when people gain weight, become obese or become diabetic, their levels of GLP-1 hormones go down, Burak said
Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes
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