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One limitation of flavonoids is their limited bioavailability, as they are rapidly metabolized in the liver and intestinal mucosa

GLP-1-based therapies, such as GLP-1 receptor agonists, glucose-dependent insulinotropic polypeptide (GIP) receptor agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors, improve glucose control through various mechanisms including increased insulin secretion, slower gastric emptying, and reduced postprandial glucagon and food intake

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This suggests that adopting these dietary strategies could potentially offer benefits akin to those provided by GLP-1 therapies in humans

During the first year, the investigators found that among patients on semaglutide, 21.6% discontinued early, 31.4% discontinued late, and 47% did not discontinue

Mitochondria function as essential regulators of cellular survival and apoptosis, serving as the primary intracellular source of ROS, which encompass free radicals like hydroxyl radical and superoxide anion, alongside non-radicals like hydrogen peroxide (Tan and Song 2023