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They respond to GLP-1, a hormone primarily produced in the gut but also in the brain, influencing metabolic, behavioral, and neuroprotective processes beyond peripheral glucose regulation
Melanotan-II (MT-2) is a synthetic cyclic heptapeptide analog of -MSH (alpha-melanocyte-stimulating hormone)
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The difference between elevated or unchanged GLP-1 levels in obese patients may be related to differences in metabolic status and detection methods, but the significant correlation between GLP-1 and lipid metabolism suggests that it can control weight and regulate lipid metabolism in HF diet groups, and GLP-1 has the potential to treat obesity caused by HF diet [102]
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