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Stress and withdrawal: DSIP attenuates basal and stress-induced ACTH release, dampening the cortisol stress response
The trial included reversion to normoglycaemia as its primary endpoint and demonstrated that semaglutide significantly increased the rate of glycaemic normalisation compared with placebo, alongside substantial reductions in BW
Trial dose range: 112mg, once weekly, subcutaneous Standard escalation: 2mg +2mg every 4 weeks 12mg (~20 weeks) Pharmacokinetics: half-life ~6 days
Similarly, 10 ug or 10ng/kg of BPC 157 was also administered to a group of test subjects through an intraperitoneal injection
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