Moreover, smoking, alcoholism, and malignancies are associated with hyperhomocysteinemia risk (Kim et al
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576 Tetrahydroxy stilbene glycoside (TSG) enhances the activation of Keap1/Nrf2/ARE and GSH/GPX4 signaling pathways, reduces ferroptosis by regulating the levels of ferroptosis-related proteins and enzymes, and thus inhibits the production and deposition of A in the brain of APP/PS1 mice, 577 suggesting that TSG may be a promising therapeutic agent for AD by targeting ferroptosis
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Current limitations include the heterogeneity of ASD, the challenges in detecting GABAergic abnormalities (e.g., reliance on invasive or low-resolution methods like MRI spectroscopy), and the need for more targeted drug development to minimize off-target effects