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Some people transition off semaglutide once theyve reached their target weight, while others continue at a maintenance dose to help prevent weight regain

You can also report suspected side effects directly via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk

We expect these changes to help drive increased savings in the weight management category after a history of delivering double digit savings for our template formulary customers year over year while expanding choice for our members

Zhang X., et al., 2020 J Cell Physiol 235 (4):3425-3437

Reviewed on Jan 02, 2026

In addition, IGF-1 LR3 may promote fat breakdown by activating the MAPK pathway, leading to increased levels of free fatty acids and further exacerbating insulin resistance, forming a vicious cycle