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Madeira, C., Alheira, F

Sibutramine, a non-selective serotonin and norepinephrine reuptake inhibitor, has been considered for patients with PWS due to its promising results in those with hypothalamic obesity [40]

While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences

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