NICE TA875 specifies that treatment should be reviewed at two years, with continuation only where clinically appropriate within the terms of the appraisal
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Cesarec V, Becejac T, Misic M, et al
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doi: 10.1046/j.1365-2826.1998.00187.x 57 KanayamaGHudsonJIPopeHGJr
Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study