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Annu Rev Physiol (2014) 76:53559

The overall fold of the L701H/T877A double-mutant AR LBD complexed with 9-fluorocortisol (PDB: 1GS4) is similar to previous agonist structures

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inhibit NCOA4-mediated ferritinophagy by upregulating XBP1 protein expression, thereby blocking lysosomal iron ion accumulation and lipid peroxidation in renal tubular epithelial cells, and significantly alleviating iron death induced by IRI