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GLP-1 signaling also antagonizes voltage-dependent K + (Kv) channels via cAMP/PKA-dependent pathway in beta cells, which prevents beta-cell repolarization by reducing Kv currents

J Cardiovasc Med

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Gut Hormone Implicated in NMOSD-Related Brain Inflammation The gut hormone glucagon-like peptide 1 (GLP-1) and its receptor (GLP-1R) may contribute to brain inflammation and nerve overactivity in patients with neuromyelitis optica spectrum disorder (NMOSD)

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Distinct experimental groups were observed under controlled conditions over an extended evaluation period