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To develop BIVID-MaP for detecting variant-specific interactions of small molecules, we first assessed how VQ-mediated covalent modification induces the three main types of RT mutations (i.e., substitution, deletion, and insertion)

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Building on striking phase 2 data which showed mean body weight reductions of approximately 24% at the highest dose over 48 weeks retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, potentially offering a more powerful metabolic effect than existing treatments

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