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Several documented crosstalk mechanisms require consideration in research design: SMAD2/3 activation by myostatin induces the expression of PTEN (phosphatase and tensin homologue), which dephosphorylates PIP3 and thereby suppresses Akt directly antagonising IGF-1R PI3K Akt signalling

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Retrieved from Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

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