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The two therapies do not share metabolic pathways or compete for the same receptors, so combining them does not create pharmacological conflicts

Innate Immun

TNF- reduced MFI compared to the IFN-, NAC, TNF-+NAC, and IFN-+NAC

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Katarzyna Otulak-Kozie, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Therefore, we hypothesized that the excessive expression of GJs post-APAP exposure in hepsin / mice could be a key factor contributing to the increased severity of liver damage observed following APAP administration