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fMRI in human studies showed GLP-1R agonists reduce neural response to food cues in reward circuits (40% striatal activation) within 2 weeks of treatment
Of note, most of the approvals so far in 2024 use at least one of the FDAs expedited approval programs
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Other documented pairings include GH-axis peptides (Tesamorelin, Ipamorelin, CJC-1295) for broader anabolic context
While anti-obesity medications suppress appetite, Schmidt said they dont inherently instill healthy habits
doi: 10.1016/j.molmet.2022.101533
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