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Butyrate Improves the Metabolic Disorder and Gut Microbiome Dysbiosis in Mice Induced by a High-Fat Diet

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By performing microarray and KEGG pathway analysis, we identified 1961 DEGs in the liver of fasted mice and fasted mice upon feeding and 42 pathways regulated by feeding (GSE184055) (Fig

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This creates a dangerous cycle: toxin buildup increases oxidative stress, which further depletes glutathione, making detoxification even less efficient