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According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness

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Fatty acid composition in major depression: decreased omega 3 fractions in cholesteryl esters and increased C20: 4 omega 6/C20:5 omega 3 ratio in cholesteryl esters and phospholipids J Affect Disord 1996

The biomarker changes were shown to correspond with endpoints such as improved gait and body composition

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This review focuses on GSH/GSSG system-based biomedical and pharmaceutical applications with relevant basic and comprehensive background information