Ascorbic acid is one of the most extensively characterized skin-active compounds in medicine, with a well-established role as a collagen synthesis cofactor and photoprotective antioxidant
Zhang et al., 2010)
Such NRF2 reduction correlates with decreased expression of its target genes, lower intracellular glutathione, and increased generation of oxidation products (Suh et al., 2004
So far, there are a few ways to predict such toxicities, including clinical examination, visual inspection, and patient-related symptoms
For most people, B12 and B Complex injections or drips are very safe and well-tolerated , especially when given in appropriate doses and by a trained professional
Pulsatility isn't a limitation to overcome