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The primary mechanism involves direct upregulation of vascular endothelial growth factor (VEGF) and VEGFR2 receptor expression a process documented across more than 40 individual published studies

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Pregnancy and breastfeeding are handled differently across products, with the weight-management versions generally advised against during pregnancy

This may overlap with the neurological sensitivity (your skin "thinks" it itches because of altered nerve signaling) or may represent a mild immune-mediated response

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