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Lassen MCH, Johansen ND, Modin D et al (2024) Adherence to glucagon-like peptide-1 receptor agonist treatment in type 2 diabetes mellitus: a nationwide registry study

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Sudden discontinuation of weight loss treatment may: Trigger rapid appetite rebound, causing a sharp increase in hunger and making it harder to maintain weight loss Lead to weight gain, as research shows abrupt stopping often correlates with faster weight regain

On the kidneys, a pooled analysis of Phase 2 obesity and type 2 diabetes data showed reductions in the standard kidney-injury marker (the urine albumin-to-creatinine ratio, or UACR) of approximately 37% in adults with type 2 diabetes and 31.5% in adults with obesity but no type 2 diabetes, both on the 12 mg dose [12]

Non-pharmacological approaches such as heat or cold therapy, physiotherapy, and lifestyle modifications should also be considered as part of a comprehensive pain management strategy