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The combined treatment demonstrated significantly greater efficacy than standard-dose pregabalin or acetyl-l-carnitine alone, in terms of both pain symptoms measured by improvement on the VAS score (+12.8%) and neurosensory symptoms measured by the DN4 tool (+22%)
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In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases (Bezin et al., 2023), which require continuous monitoring and evaluation
[8] One such potential pathway involves the activation of phospholipase C (PLC), which researchers suggest may lead to the release of inositol triphosphate (IP3) and diacylglycerol (DAG)
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(2022) in Cell Metabolism provides the foundational discovery data
