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By activating GLP-1 receptors, Retatrutide markedly improves insulin sensitivity, promotes satiety, and reduces caloric intake, thereby directly combating insulin resistance and hyperglycemia, core drivers of accelerated aging
With diabetes and CKD projected to be the seventh and fifth leading cause of premature mortality worldwide by 2040, respectively [7], novel and effective treatment options are critical
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The figure legend notes that multiple acyl-CoA dehydrogenase deficiency (MADD) results from mutations in the genes coding for the ETF or ETF-QO
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