LC-MS is particularly valuable for identifying oxidation, deamidation, isomerization, lipid-chain modifications, and peptide truncations, which are common in GLP-1 peptide drugs
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While the average person needs about 1 gram of lysine a day for optimal body function, the maximum amount that has been studied for benefit is 4 grams per day, Wheeler says
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[59] when using a higher VPA dosage (4 mM)