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Stop using metformin and seek medical attention if you experience signs of lactic acidosis including confusion, fast breathing, fast or slow heartbeat, severe stomach pain, upset stomach or vomiting (especially later in treatment), feeling very tired or weak, severe dizziness, muscle pain or cramps, or feeling cold

It is EMA-approved (as Scenesse) for the prevention of phototoxicity in adults with erythropoietic protoporphyria (EPP) and has been investigated for broader photoprotective applications

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For example, spatial transcriptomic analysis of the mouse brain revealed that depression is closely linked to gene expression changes in specific regions, including the hippocampus, isocortex, and amygdala