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Shorakae S, Teede H, De Courten B, Lambert G, Boyle J, Moran LJ
This sequestration is important to remove the glutathione conjugate from the cytoplasm for several reasons including the instability of glutathione conjugates
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These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism
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