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During semaglutide therapy, patients with a history of diabetic retinopathy should be closely monitored
Active ingredient: The active ingredient in Trulicity is dulaglutide which is 90% similar to human GLP-1
The peak-to-trough variation in drug levels with daily oral dosing versus weekly injectable dosing may also affect overall efficacy, particularly for outcomes like appetite suppression that benefit from steady drug levels
WADA has banned it under the S0 Unapproved Substances category
The gut microbiota can also alter drug metabolism, affecting therapeutic efficacy and toxicity
Weight loss continued through 52 weeks without plateau, suggesting potential for further reduction with longer treatment duration.7 Maridebart cafraglutides peptideantibody conjugate design confers a long pharmacokinetic half-life, allowing for monthly dosing, which may significantly improve treatment adherence and convenience compared with weekly injectable regimens
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