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PDK4 expression is high in heart, liver, pancreatic islets, and kidney and each of these tissues are capable of high rates of fatty acid oxidation and also express high levels of the transcription factors PPAR and PPAR which are known to be critical regulators of the expression of genes encoding lipid metabolizing enzymes
Lancet 384 , 607617 (2014)
This protocol may be considered a potential future therapeutic intervention for PCOS, though further clinical investigations are required
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Hence, there is low level of IGF in theca cells resulting from follicles medium in size, also in neonatal ova, while IGF-2 expression is high in the isolated granulosa cells from antral follicles
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